Universal health care coverage states that every sovereign state should provide health care and protection to all citizens on the framework of equity .The costs that exceed 40% of the household income are called catastrophic out of pocket payments. In Pakistan, out of pocket expenditures are around 70% of the total health expenditures.1 The objective of this current study is to determine the burden of Cancer costs that a household faces while being admitted in the tertiary care hospital for (at least six months and more) in Rawalpindi and Islamabad territory. A logistic regression model is used to determine the determinants of catastrophic out of pocket payments for cancer treatment. Stratified random sampling is for data collection with the total sample size of 500. The study has employed several quantifiable measures and tools in determining the extent of “catastrophic” incidence and intensity on the Household. In this analysis the interviews of cancer patients was carried out in the three most reputable hospitals within Islamabad and Rawalpindi Territory. This includes CMH, NORI and PIMS, the inflow of cancer patients coming into these hospitals belonged to the region of AJK, Punjab, KPK, GB, Sindh and Afghanistan. In the present analysis it is deduced that the most common type of cancer diagnosed among males was larynx while among females the most prevalent type of cancer was Breast. The average age bracket of both Male and a female cancer patient was from 18 to 54 years. This age bracket constitutes the most productive part of one’s lifetime. The average income of most of the respondents was less than 10,000 PRs while the total cost (total direct cost + total indirect cost) for cancer treatment within a month is at-least 1,671,437 PRs in AJK 3,720,300 PRs in Punjab, 2, 930,600PRs in KPK, 2,668,500 PRs in GB, 1,364,526 PRs in Sindh and 2,433,300 PRs in Afghanistan. The catastrophic impact of out of pocket payments were felt by at-least 445 out of 470 cancer patients which shows the absence of financial protection and the neglect of social protection programs regarding the financial protection of Cancer Patients which ultimately pushed them towards impoverishment. Supervisor:- Dr. Fatima Sharif