Digital Business Ecosystem is one of the most important factors to make the project successful. The purpose of this study was to analyze the enterprise resource planning moderating effect on the digital business ecosystem on the competence knowledge of the technology and the business environment of IT companies (SMEs) of Pakistan. The questionnaire was distributed among the respondents and 216 questionnaires were recorded for the data analysis process. Questionnaires were distributed among the employees of small and medium enterprises (SME’S) i.e. Islamabad, Rawalpindi, Lahore, and Faisalabad. To analyze the result, I utilized the method of structural equation (PLS-SEM) using the SmartPls software. This technique is applied to the data of 216 employees of small and medium enterprises. The first step is to find out the relationships between Technology, Business Environment, Competence Knowledge and Digital Business Ecosystem with the moderation effect of Enterprise Resource Planning. After the analysis, we find out that the moderation effect of Enterprise Resource Planning on Technology and Competence Knowledge and also on Business Environment is insignificant with the viewpoint from Pakistan, so we reject the hypothesis because there is no relationship between them. Supervisor:- Dr. Muhammad Nadeem Ahmad Khan