This study assesses the impact of pesticide use in cotton crops on sprayer’s health in two tehsils: Mian Channu and Bhuwana. Tehsil Mian Channu has a Pest Control Department which overlooks the pesticide use practices while it is absent in Tehsil Bhuwana. This difference is the base of conducting a comparative study to see the differences in the health problems faced and associated health costs incurred by the sprayers of Mian Channu and Bhuwana. The total sample of sprayer respondents was 250 out of which 150 sprayers belonged to Tehsil Mian Channu and 100 belonged to Tehsil Bhuwana. Using Dose Response Function and Health Cost Function, the study finds that increased exposure to fumes, un-observance of protective gears, using banned pesticides, and absence of Pest Control Department greatly increases the incidence of pesticide related diseases and health cost of sprayers of Tehsil Bhuwana compared to sprayer of Tehsil Mian Channu. This study recommends establishment of a pest control department in tehsil Bhuwana and provision of incentives to sprayers to use certified pesticides products instead of the banned pesticides. Supervisor:- Dr. Rehana Siddiqui