The objective of this study is to measure the economic burden of breast cancer disease in female population. Breast cancer is most common cancer all over the world. This fatal disease in women of the low, middle and high-income countries has created heavy economic burden on the household. It is the most common cancer affecting women with the estimated life time risk for 1 woman out of 8 women (1/8). About 1.3 million women are diagnosed with breast cancer worldwide each year, with total of 465,000 deaths. The prevalence of the disease is increasing with the age of the patients. 80% of the women diagnosed with this disease are over fifty years of the age. Reproductive factors, such as early menarche, late menopause, and late age at first childbirth are among the most important risk factors for female breast cancer patients. Breast cancer forces a huge economic burden on households. therefore, the policy makers and health planners are interested in understanding the economic cost of illness to measure the allocation of resources to the cancer institutions and hospitals as allocation to nuclear medicines disease categories and to evaluate the possible costs and benefits. From a social side breast cancer is a disease that in addition to contributing to mortality and disability increases a major public and private economic burden. convenient sampling used for data collection with the total sample size of 225. the interviews of breast cancer patients were conducted in the two-hospital situated in the capital territory of Islamabad, Nuclear Medicine, Oncology & Radiotherapy Institute and Surgical Center. The methodology of the study is based on two section which is descriptive statistics and empirical estimations. The study has used OLS (Ordinary Least Square) estimation technique to determine the factors influencing breast cancer cost. The study found that, stage and treatment duration is increasing the breast cancer cost and the inflow of cancer patients coming into these hospitals from region of Punjab, Azad Jammu Kashmir (AJk), Sindh, Baluchistan, Islamabad. Most of the respondents reported high intangible burdens including fear, pain emotional suffering and family management having breast cancer majority of the patients experienced a lot of psychological problems due to their illness. Supervisor:- Dr. Ahsan ul Haq Satti