This study is an attempt to know about the influencing factors behind fishery loss in the River Swat, Khyber Pakhtunkhwa. The study used primary data applying multiple linear regression model alongside descriptive statistics for the analysis. Study finds that pH of water, ammonia level, hotel waste, cities garbage and destructive fishing practices are the main factors behind fishery loss in river Swat. The result reveal that pH of water, ammonia, hotel waste and cities garbage have negative impact on fisheries resources. Besides, institutional arrangements for the conservation of fisheries resources in district swat are limited. The water quality must be protected from wastes generated from households, hotels and Mingora city. Fishers should be given education regarding tools and methods used for fishing. There should be awareness campaign to control illegal fishing and water pollution in river Swat. Supervisor:- Dr. Anwar Hussain