Economic Corridors serve as a catalyst for the sustainable development in a region. China- Pakistan Economic Corridor is also expected to become a breakthrough for the regional as well as national development of Pakistan and China in a multi-dimensional aspect. As it is portrayed as a ‘Game Changer’ for Pakistan, therefore, it is important to assess the capacity of the districts included in the three routes that whether they are capable enough to absorb mega investment of $64 billion for the development in multi-variant domains and to highlight the potential strengths and weaknesses of the selected districts in chosen 8 domains. This study will provide a benchmark for the selected districts from three routes on seven domains of development sector including demography, education, agriculture, health, infrastructure & housing, industry and environment. It also covers the policy initiatives taken by other countries with such economic corridors (The Greater Mekong Sub region). The methodology adopted for this study covers both quantitative and qualitative analysis through ranking of the districts based on their performance against each indicator and desk review of the international best practices for policy initiatives. The assessment of these districts on the said domains implies that the districts on Eastern Route are more developed and well-equipped in the above mentioned domains whereas the Central and Western Route with an exception of Karachi and Peshawar are lagging behind in all domains. Therefore, these two routes need immediate attention of the relevant stakeholders of CPEC and policy makers in order to extract substantial benefits from the CPEC. On the basis of findings, it is suggested that the agenda of CPEC must be aligned with the frameworks of Sustainable Development Goals and Vision 2025 by focusing three areas of development that are human resource development, agriculture sector and prioritization of potential districts for the promotion of domestic growth. The study have useful policy implications for the inclusive domestic development of the districts. Policymakers from both countries may utilize these findings to workout practical ways to harness the true potential of CPEC on regional as well as district level. Supervisor:- Dr. Iftikhar Ahmad Co-Supervisor:- Ms. Lubna Hassan